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Coincubation as miR-Loading Strategy to Improve the Anti-Tumor Effect of Stem Cell-Derived EVs

Published at mdpi Pharmaceutics
2021
by Alessia Brossa, Marta Tapparo, Valentina Fonsato, Elli Papadimitriou, Michela Delena, Giovanni Camussi and Benedetta Bussolati

News: Unicyte submits Clinical Trial Application for potentially life-saving therapy

Unicyte submits Clinical Trial Application for potentially life-saving therapy for pediatric patients with urea cycle disorders, setting the stage for patient enrollment in H2 2022 Unicyte AG, a clinical-stage development company innovating the field of regenerative medicine, today announced the submission of a Clinical Trial Application (CTA) in Europe for a Phase 2 trial (reLiver-2) designed to assess the safety and efficacy of its proprietary human liver stem cell (HLSC) therapy, HLSC-001, in pediatric patients with early-onset urea cycle disorders (UCD). HLSC-001 is being evaluated in these patients initially as a bridging therapy prior to liver transplantation with the option and ultimate goal to provide a curative therapy. The company expects to initiate patient enrollment in the second half of
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Human liver stem cell-derived extracellular vesicles reduce injury in a model of normothermic maschine perfusion of rat livers previously exposed to a prolonged warm ischemia.

Published at Front Cell Dev Biol.
©2021
by Bruno S, Herrera Sanches MB, Chiabotto G, Fonsato V, Navarro-Tableros V, Pasquino C, Tapparo M, Camussi G.

HLSC

Human Liver Stem Cells: A Liver-Derived Mesenchymal Stromal Cell-Like Population With Pro-regenerative Properties.

Published at Transplantation Int.
©2021
by De Stefano N, Navarro-Tableros V, Roggio D, Calleri A, Rigo F, David E, Gambella A, Bassino D, Amoroso A, Patrono D, Camussi G, Romagnoli R.

HLSC

Extracellular vesicles from human liver stem cells inhibit renal cancer stem cell-derived tumor growth in vitro and in vivo.

Published at J Mol Sci
®2020
by Alessia Brossa, Valentina Fonsato, Cristina Grange, Stefania Tritta, Marta Tapparo, Ruggero Calvetti, Massimo Cedrino, Sofia Fallo, Paolo Gontero, Giovanni Camussi and Benedetta Bussolati.

nEVs

Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice.

Published at Sci Rep
©2020
by Famulari ES, Navarro-Tableros V, Herrera Sanchez MB, Bortolussi G, Gai M, Conti L, Silengo L, Tolosano E, Tetta C, Muro AF, Camussi G, Fagoonee S, Altruda F.

HLSC

Intrahepatic Administration of Human Liver Stem Cells in Infants with Inherited Neonatal-Onset Hyperammonemia: A Phase I Study.

Published at Stem Cell Rev Rep.
®2020
by Spada M, Porta F, Righi D, Gazzera C, Tandoi F, Ferrero I, Fagioli F, Sanchez MBH, Calvo PL, Biamino E, Bruno S, Gunetti M, Contursi C, Lauritano C, Conio A, Amoroso A, Salizzoni M, Silengo L, Camussi G, Romagnoli R.

nEVs

Extracellular Vesicles Released by Tumor Endothelial Cells Spread Immunosuppressive and Transforming Signals Through Various Recipient Cells.

Published at Front Cell Dev Biol.
®2020
by Lopatina T, Favaro E, Danilova L, Fertig EJ, Favorov AV, Kagohara LT, Martone T, Bussolati B, Romagnoli R, Albera R, Pecorari G, Brizzi MF, Camussi G, Gaykalova DA.

nEVs

Extracellular Vesicles From Adipose Stem Cells Prevent Muscle Damage and Inflammation in a Mouse Model of Hind Limb Ischemia: Role of Neuregulin-1.

Published at Arterioscler Thromb Vasc Biol.
®2020
by Figliolini F, Ranghino A, Grange C, Cedrino M, Tapparo M, Cavallari C, Rossi A, Togliatto G, Femminò S, Gugliuzza MV, Camussi G, Brizzi MF.

nEVs

Molecular Pathways Modulated by Mesenchymal Stromal Cells and Their Extracellular Vesicles in Experimental Models of Liver Fibrosis.

Published at Front Cell Dev Biol.
®2020
by Chiabotto G, Pasquino C, Camussi G, Bruno S.

nEVs

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